DDW+H2, Better (or Best) for cancer patients under palliative treatment?

In many cancer research papers we can see this kind of words–

Cancer in the developing world is characterized by far more advanced stages at diagnosis, fewer allocated resources for prevention and treatment, and higher incidence than in countries with more developed health systems.

This means a higher percentage of cancer patients in developing countries need palliative treatment.

National Cancer Institute of United States defined palliative care as:

( https://www.cancer.gov/about-cancer/advanced-cancer/care-choices/palliative-care-fact-sheet )

Palliative care is care given to improve the quality of life of patients who have a serious or life-threatening disease, such as cancer. Palliative care is an approach to care that addresses the person as a whole, not just their disease. The goal is to prevent or treat, as early as possible, the symptoms and side effects of the disease and its treatment, in addition to any related psychological, social, and spiritual problems.  Palliative care is also called comfort caresupportive care, and symptom management. Patients may receive palliative care in the hospital, an outpatient clinic, a long-term care facility, or at home under the direction of a physician.

Basically it is about treating symptoms of the disease and treating side effects of cancer treatment.

Among all the symptoms caused by late stage cancer the hardest to treat is PAIN.

Side effects caused by cancer treatments (chemotherapy and/or radiotherapy) may include but not limited to fatigue;  pain such as Headaches, Muscle pain, Stomach pain and Pain from nerve damage (such as burning, numbness, or shooting pains, usually in the fingers and toes) ; Mouth and throat sores (usually happen 5 to 14 days after a treatment); Diarrhea; Nausea and vomiting; Constipation (having difficult bowel movements); Blood disorders; Nervous system effects (Tingling, Burning, Weakness or numbness in the hands and or feet, Loss of balance, Shaking or trembling ).

Pain management medications include:

Opioid; You might take morphine type (opioid) painkillers for mild, moderate and severe pain.

Non opioid painkillers are often used for mild to moderate pain. You can also take them alongside stronger painkillers for more severe pain.

You might take other drugs alongside painkillers to help relieve cancer pain. These might be steroids, anti depressants or anti epileptic drugs.

Global shortage of opiod:

Americans are in more pain than any other population around the world. At least, that’s the conclusion that can be drawn from one startling number from recent years: Approximately 80 percent of the global opioid supply is consumed in the United States.  United States,  Canada and Western Europe together consume 95% of global opioid supply. So the remaining countries only have access to about 5 % of the opioid supply.


We can see that there are real problems for developing countries to cope with cancer (and other diseases) patients under palliative treatment which normally need pain relief medications like opioid and its derivatives.

Lately a Taiwanese company had developed a high-tech product which probably can be consumed as liquid food supplement which exhibits quite notable pain relief effect. The product is deuterium depleted water with saturated hydrogen (DDW+H2).

Daily consumption of DDW+H2 may gradually eliminate side effects of curative/palliative cancer treatments. For cancer patients under no treatment,  it may serve for pain relief.



Current Status of Palliative Care Nursing in Egypt: Clinical Implementation, Education and Research

Karima Elshamy  *Medical Surgical Nursing, Faculty of Nursing, Mansoura University, V P of African Organization for Research and Training in Cancer of North Africa, Founder and Executive Director of Egyptian Society for Women’s Health, Egypt

Corresponding Author:
Elshamy K, DNSc
Assistant Professor of Medical Surgical Nursing
Faculty of Nursing, Mansoura University, Egypt
Tel: +2 01157271778
Email: karima_elshamy2002@yahoo.com

Received Date: October 06, 2015; Accepted Date: November 21, 2015; Published Date: November 25, 2015

Citation: Elshamy K (2015) Current Status of Palliative Care Nursing in Egypt: Clinical Implementation, Education and Research. J Palliat Care Med S5:005. doi:10.4172/2165-7386.1000S5005

Copyright:© 2015 Elshamy K, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Cancer in the developing world is characterized by far more advanced stages at diagnosis, fewer allocated resources for prevention and treatment, and higher incidence than in countries with more developed health systems. In Egypt, it is already and will become an important health problem not only in terms of rank order, but also in terms of incidence and mortality. The commonest sites were liver among men and breast among women. During the period 2013–2050, population of Egypt is expected to increase to approximately 160% the 2013 population size. Applying the current age-specific incidence rates to successive populations would lead to a progressive increase in number of incident. The resources for cancer control in Egypt are directed almost exclusively to treatment. Most cancers present at an advanced stage (stage III and IV) when cure is improbable even with the best treatments. Comprehensive cancer care requires the integration of palliative care practices and principles across the trajectory of the cancer experience and may be the sole focus of care for those patients with advanced incurable disease. As the incidence of cancer increases worldwide and the burden of cancer rises, especially in low and middle resource countries, the need for palliative care is greater than ever before and this care is most effectively provided by a multidisciplinary team. According to WHO, 40% of cancers could be avoided (prevention), 40% could be cured (if detected early) and the rest should be managed with palliation. So, expansion of palliative care services to a larger number of patients and illnesses throughout the country, considering home-based palliative care service is urgently and badly needed, strengthening health care systems; focusing on patient centred care, education and training to all levels of health care professionals.


Palliative care; Clinical aspects; Education; Research; Egypt


Cancer is a global and international problem. It is the second leading cause of death worldwide after heart and vascular disease. It accounted for 8.2 million deaths in the year 2012. Among the most frequent causes of death are liver, stomach, colorectal and breast cancers. Unfortunately, annual cancer cases are expected to rise from 14 million in 2012 to 22 million within the next two decades [1]. Diagnosis of cancer and its treatment can have a devastating impact on the quality of a patient’s life, as well as on the lives of families and other care givers. Patients face new fears, uncertainties and may have to undergo unpleasant and debilitating treatments. Therefore, patients and their families need access to support from the time that cancer is first suspected, through all stages of treatment to recovery or, in some cases, to death and into bereavement [2]. Patients with advanced cancer experience a range of complex problems that cannot always be dealt with effectively by generalist services. Therefore, they require a range of services to ensure that their physical, psychological, social and spiritual needs are met effectively and to enable them to live and die in the place of their choice. Thus, hospices and specialist palliative care services should be accessible and available [3].

Palliative care is the active holistic care of patients with advanced, progressive illness. Management of pain and other symptoms and provision of psychological, social and spiritual support is paramount.

The goal of palliative care is achievement of the best quality of life for patients and their families. Many aspects of palliative care are also applicable earlier in the course of the illness in conjunction with other treatments [4]. Palliative care goes beyond the traditional medical model to focus on psychosocial issues, spiritual matters, medical decision-making, and on the relief of suffering in all its dimensions throughout a person’s illness [5]. Because of its focus on the whole person, more experts are advocating that a palliative approach to care could and should be integrated into care for all people with chronic, life-limiting conditions (including cancer). The rationale for integrating palliative care into chronic disease management is the recognition that people with chronic diseases often have a long illness trajectory and, during that time, may have different palliative care needs. As their disease progresses, they may experience a complex range of social and emotional needs including isolation, decreased independence and burden on family members. Most people with chronicillnesses other than cancer often reach the terminal phase of their life without having been offered many of the physical and social resources available through palliative care [6].

Definition of palliative care

Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with lifethreatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocialand spiritual. Palliative care: provides relief from pain and other distressing symptoms; affirms life and regards dying as a normal process; intends neither to hasten or postpone death; integrates the psychological and spiritual aspects of patient care; offers a support system to help patients live as actively as possible until death; offers a support system to help the family cope during the patients illness and in their own bereavement; uses a team approach to address the needs of patients and their families, including bereavement counselling, if indicated; will enhance quality of life, and may also positively influence the course of illness (Figure 1), is applicable early in the course of illness, in conjunction with other therapies that are intended to prolong life, such as chemotherapy or radiation therapy, and includes those investigations needed to better understand and manage distressing clinical complications [7].

An overview of Egypt

The land and geography: Egypt lies in North Africa bordering the Mediterranean Sea and Red Sea, is between Libya and the Gaza Strip and North of Sudan. Egypt includes the Sinai Peninsula which forms a “land bridge” in Southwest Asia. 90% of Egypt is desert; the majority of the people live near the banks of the Nile River where suitable land for cultivation can be found. The majority of the 80 million Egyptians reside in 3% of the total geographic area. Cairo, the capital city and Alexandria are the major inhabited centers (Figure 2).

Language: For almost 13 centuries Arabic has been the written and spoken language of Egypt for both the Egyptian Christian and Muslim. However, most Egyptians understand and speak English and French. English and French are widely used for business and by educated urbanites. [8].

Religion: Approximately 85 percent of the populations of Egypt are Moslems. Most of the balance, about 9 million, is Christian Orthodox who belongs to the Coptic Church. In most cities in Egypt, mosques and churches can be found next to each other. There are also some synagogues since a small Jewish community still lives in Egypt [8].

Medicine and health care

Naturalistic and social causes of sickness include bad luck, stress and bereavement; for children loss of love, germs, wind and drafts, hot/ cold, imbalance and fear. Supernatural causes are Evil Eye (most Arabs believe in Evil Eye and keep special amulets during illness), God’s punishment for sins and the curse of the devil.

Illness and suffering are believed to be god’s will.

Mental illness is highly stigmatized and help is sought in advanced stage. The Zar, a ‘trance religious ceremony’, using drumming and dancing is thought to cure mental illness caused by a demon.

Disabled are treated with compassion and indulgence, and kept from the public as those with genetic defects; genetic counselling is generally refused.

Institutional care is shunned. Egyptians will likely combine the present health system with traditional beliefs and customs for the purpose of healing.

Camphor ointment, herbs as teas and poultices are used to treat cold, abdominal discomfort, musculoskeletal aches and pains.

In Egypt, there are the traditional health practitioners such as seers and spirit healers. When the Arabs came to Egypt, Arabic medicine was practiced. These traditional herbal medications are available in Attar shops and an increasing number of Egyptians are seeking herbal remedies because they are cheap and viewed as safer.

Medical professionals should avoid frank discussions of diagnosis and poor prognosis.

Families may prefer to tell the information to the patient, but may ask a healthcare provider to be in attendance.

The information should be given gradually and in a prolonged manner. Arab patients express their pain comparing it to fire, knives, rocks and iron.

The patient’s concentration is on the present pain experience. The pain scale response may not indicate the actual acuity, for example, minor pain may be reported as a 10. Pain injections are thought to be more effective than pills.

Most patients and families may avoid activities after surgery such as ambulation, coughing, and physical therapy for fear of pain and prolonging the disease.

Admittance of depression and symptoms of depression are never disclosed. Verbal permission based on trust is more acceptable than written consent.

Patients and their families do not like knowing about the potential complications before a medical procedure because it is thought to be bad luck [9].

Death and the afterlife

Death is feared, accepted as “God’s will”, but believe death should be delayed by biomedical interventions. Critically ill patients may prefer to die in the hospital. Families will not openly grieve before death of family member; they will however grieve openly and loudly and a private room may be beneficial. After death Christians and Muslims try to bury the body the same day. Koran reading may be an indicator of the Islamic condolence sessions. Condolences are expressed without delay, and again after 40 days and after a year.

Christian Families may ask a minister or priest visit. Egyptian Muslims do not need an Imam present. Egyptian Muslims handle the body by same gender Muslim with modesty; oropharyngeal orifices are sealed with cotton, the body is covered with a sheet and turned towards Mecca [9].

An Overview and Profile of Frequent Cancers

The population size of Egypt: Currently, Egypt is experiencing significant size, age structure changes that will have major implications for its socioeconomic development. The population size of Egypt increased from 44.9 million in 1980 to approximately 78.1 million in 2010, and 80,722,000 in 2014.It is projected that in 2050, the population size of Egypt will reach approximately 121.8 million as shown in (Figure 3) [10].

Cancer mortality profile: According to World Health Organization – Cancer Country Profiles, 2014, 39,300 deaths were among males, and 33,000 deaths were among females as illustrated in Figure 8.

Current Status of Palliative Care Nursing In Egypt

A-clinical implementation

In most of the world, the majority of the cancer patients present with advanced disease. For them, the only realistic treatment option is pain relief and palliative care. Effective approaches to palliative care are available to improve the quality of life for cancer patients. Lack of access to basic pain relief continues to make living and dying with cancer in Egypt a very different experience from that in developed countries.

The National Cancer Institute (NCI) in Cairo was established in 1969 as a specialized institute, affiliated with Cairo University. In 2004, palliative care was included in the oncology medical training programme at the National Cancer Institute at the University of Cairo. In 2006, there were two organizations providing hospicepalliative care in Egypt: the Cairo Evangelical Medical Society (which has hospice facilities in Cairo and Alexandria) and the National Cancer Institute (which puts an emphasis on cancer pain relief).

In 2010, the NCI, Cairo has cared for 18 156 new patients which comprised 70-80% of all cancer patients in Egypt. A total of 70% of all new cancer patients were diagnosed with an advanced stage of the disease. NCI’s first initiative towards the development of palliative care services was in 1981 when the first pain clinic was established as part of the Department of Anaesthesiology. This clinic handles 120-150 patients daily, while slow release morphine tablets are the only available pain medicine [11]. At the present, NCI is running a pain care clinic at its outpatient pain department. This clinic operates on a the capacity of a 24 hours/7 days basis, and its staff (multidisciplinary team) comprises pain management physicians, specialized nurses, clinical social workers, pharmacists, psychiatrists, dietitians and administrative manpower.

In addition, a hotline service was established, thus enabling easier access to the experts on the team. In addition to the NCI, Cairo, the Kasr Elaini Cancer Center in Cairo also runs a pain clinic and a palliative care service started in 2007. The new Children’s Cancer Hospital 57357 in Cairo runs pediatric palliative care services including psychological support. The Cairo Evangelical Medical Society provides in-patient and day care hospice services (opened in 2001), while similar services are provided by the Elhadra Elromany hospice in Alexandria [11].

Palliative care in Egypt is in an early stage of development with very few palliative care activities available even in all of the above specialized Centres. At this stage, research is crucial to develop suitable palliative care models with respect to the needs, culture, and resources in Egypt. In addition, a range of health professionals, other workers, carers and volunteers provide palliative care services: nurses, including registered and non-registered nurses with and without specialized palliative care qualifications, medical practitioners, including specialist palliative care physicians, hospital-based specialist palliative care trainees, hospital-based non-specialists and general practitioners(GPs),health professionals, including psychologists, physiotherapists, occupational therapists and pharmacists, volunteers, carers, including both formal and informal carers. While palliative care can be provided to patients in a variety of settings, a distinction is commonly made between care provided in hospitals (which includes hospices or dedicated palliative care wards) and the community (such as in the patient’s home or in residential aged care facilities).

Opioid consumption: Figures in Egypt are among the lowest worldwide indicating largely inadequate cancer pain control. Based on the data published in the most recent annual report of the International Narcotics Control Board, the average opioid consumption in Egypt during 2008-2010 was 62 defined daily dosed for statistical purposes (S-DDD) per million inhabitants per day. With this Figure, Egypt was ranked 115th among 184 countries [12].

In Egypt, palliative care and cancer pain control are at an early stage of development. Very few services are available, and there are many barriers to be faced, such as limited opioid accessibility and availability for medical use. Palliative care is still misunderstood among health professionals, cancer patients and the public at large. One reason to that is because the term does not obviously communicate the intent of this clinical discipline, which is lending better quality of life while combating cancer.

The Society for the Management of Pain was founded in Egypt in 1980. A postgraduate training program was subsequently established to equip physicians with advanced knowledge and skills in pain management.Parenteral morphine is locally manufactured whereas oral preparations are imported. One Egyptian experience that could have possible implications for other Muslim communities is the success that Egypt has had in training patients’ relatives to care for patients in their homes. A patient’s relative is selected as the principal caregiver and is then given basic teaching on the disease and some tips on patient care at home. The home caregiver is provided with a booklet that contains a daily observation sheet, which is completed by the caregiver and reviewed by the health professionals weekly [13].

Practice: Only a few healthcare providers have adequate knowledge of pain assessment and management and palliative care, so, it is important to integrate pain and palliative care into the health unites.

Egypt has National Guidelines for the management of acute and chronic pain, management of other physical symptoms. New guidelines are currently worked out for End-of-Life Care and for home-based hospice services. National guidelines for palliative care were not initiated till now. The NCI, Cairo offers MD and Master degrees in pain management and palliative care has been incorporated in the curriculum of the oncology nursing program in the same institute.

Ethical, Religious and Cultural Issues

All patients probably undergo the stages of acceptance of terminal cancer in the same fashion. The difference between Egyptian and Western cultural practices would likely be in the culturally specific coping strategies. Ultimately, the physician and other healthcare providers have to assess the patient in his cultural context and find out what would help the patient the most to go through the terminal phase of the disease. The community bond amongst Muslims is very strong, most end of life issues are preferably taken care at home amongst family members rather than in hospice facilities.

In dealing with a patient, a physician must take into account the degree of his cultural inclinations as well as that of his family in order to communicate and provide best medical treatment effectively. Invariably, communication and empathy are indispensable in achieving this. In an increasingly westernizing society, a physician should be wary of imposing generalized belief models on patients without first understanding their background and preferences.

Islam is the dominant religion in Egypt, and observant Muslims believe that having an illness represents an opportunity to enhance the Muslim’s degree or expiating personal sins. Yet, Islamic teaching encourages Muslims to seek treatment when they fall sick, as it is believed that Allah did not send down a sickness but rather a medication for it [14]. Muslim’s beliefs attribute to occurrence of pleasure and suffering to the will of Allah, and that every effort should be made to relieve suffering. Moreover, Islamic teaching considers the relief of suffering to be highly virtuous [15]. According to Islam, adults of both genders are granted the full right to accept or decline medical intervention. In reality, close family members are more often directly involved with the decision-making process. Generally, parents, spouses and older children, in descending order, have greater decision-making power than the other members of the family [16].

Islamic teaching encourages the community members to visit the sick and the sick to welcome their guests. Patients, therefore, may entertain a larger number of visitors during their hospitalization [14]. The use of drugs that might affect consciousness is strictly prohibited in Islam. However, medically prescribed opioids are generally permissible because of their necessity. Usually, patients and families accept the use of opioids for symptom management, provided the rationale for their use is clearly explained to them. Of great importance is to explain patients and their relatives the possible side effects, as there are great concerns about an imposed drowsiness [17].

Issues that relate to end-of-life are compounded spiritually and ethically, and are open for interpretations. While discussing the prognosis of the loved one, Muslim families are often sceptical about receiving clear cut massages from the treating physician. The former are for the most part more comfortable receiving less concrete information and quite often would respond with: ‘This is in Allah’s (God’s) hands, and we are not to predict the fate of the patient’. Such a response is largely due to the Islamic belief that the life expectancy of every person is only up to Allah, who is the one to determine the timing of death. Families, however, are very appreciative being updated as to the patient’s condition, in order to enable them to carry out the traditional funeral rites. Taking all of the above into consideration, caregivers in Egypt exercise all the precautions and sensitivity while talking to terminally ill patients and their families [11].

Culture and Religion on Commutating Bad News At the End of Life

In Islamic ethics, family and community are intrinsically linked with each individual’s well-being [18]. Similarly, in many Asian cultures, illness is a shared family event rather than an individual occurrence [19]. The family provides a source of strength, hope and connectedness to others. Accordingly, the principle of autonomy does not bear the same weight as it does in many Western cultures and thus the family is the locus of the decision-making process [20]. A Japanese study [21] found that 46% of the population felt it was the family’s duty to provide ‘a protective role in shielding the patient from a painful diagnosis [18]. Equally, in Ethiopia and Saudi Arabia, information regarding a patient’s illness belongs to the family, who then use the information in the best interests of the patient. Physicians, consequently, respect the ‘autonomy of the family as a unit’ [20].

Methods to improve application of palliative care principles

Palliative care guidelines provide a framework for the care needed for patients with serious and life-threatening cancers. Approaches to improving the application of this care include education, training, and research endeavours.

Palliative Care Education and Training

Undergraduate education: The concepts of pain have been integrated into the education of nurses at some faculties and schools of nursing. . Little attention has been paid to the education and training of health professionals on palliative care. Little information has received in undergraduate palliative Care education. Most have acquired knowledge and skills after graduation

Postgraduate education: The concepts of pain, palliative care and end-of-life content are integrated throughout most of contents in Egyptian nursing faculties for postgraduate nursing curricula. In addition, assessment and management of palliative nursing is accomplished through palliative Care clinical education, bedside teaching, and working in a variety of clinical areas, conferences and workshops. Some of Egyptian nursing faculties offer a hospice and palliative care courses. Students have the opportunity to chose and interact with palliative care team in hospitals, attend palliative care training program, and investigate palliative care and hospice care as delivered at hospital settings. The faculty of nursing palliative care training program and end-of-life (EOL) care focuses on the following contents:

Pain management that include: definitions of pain, current status of and barriers to pain relief, components of pain assessment, specific pharmacological and non-pharmacological therapies including concerns for different patients

Symptom management: Detailed overview of symptoms commonly experienced at the EOL, and for each, the cause, impact on quality of life, assessment, and pharmacological/non-pharmacological management.

Ethical/Legal issues: Recognizing and responding to ethical dilemmas in EOL care including issues of comfort, consent, prolonging life, withholding treatment; euthanasia, and allocation of resources; and legal issues including advance care planning; advance directives, and decision making at EOL.

Cultural considerations: End-of-life care, multiple aspects of culture and belief systems, components of cultural assessment with emphasis on patient/family beliefs about roles, death and dying, afterlife, and bereavement.

Communication essentials: Communication at EOL, attentive listening, barriers to communication, breaking bad news, and interdisciplinary collaboration.

Nursing care at the end of life: Overview of death and dying in Egypt, principles and goals of hospice and palliative care, dimensions of and barriers to quality care at EOL, concepts of suffering and healing, role of the nurse in EOL care.

Grief, loss, bereavement: Stages and types of grief, grief assessment and intervention, and the nurse’s experience with loss/grief and need for support.

Achieving quality care: End-of-life challenge for nursing in EOL care, availability and cost of EOL care, the nurses’ role in improving care systems, opportunities for growth at EOL, concepts of peaceful or “good death,” “dying well,” and dignity.

Preparation and care: Time of death nursing care at the time of death including physical, psychological, and spiritual care of the patient, support of family members, the death vigil, recognizing death, and care after death.

Currently there is no postgraduate training in pain management or palliative care in Egypt. To effectively manage the large number of patients in need of palliative care services, Egypt should have adequate numbers of specialists in pain management and palliative care who in turn can support the primary care providers in the management of difficult and complex pain patients across Egypt. It is suggested that postgraduate training programs be developed for both doctors and nurses who wish to acquire special expertise in pain management and palliative care. Certification of healthcare workers in pain management and palliative care should be instituted. It is recommended that palliative care should be integrated into the undergraduate training provided by all medical and nursing schools in Egypt, and to be integrated into all examinations of doctors and nurses.


Current status

Egypt has significant quantitative and qualitative palliative care researches that were done by nursing, medical, psychological professionals these researches are directed at improving the care of seriously ill patients and their families, improving the clinical practice, symptom control in advanced cancer, and interventions for ICU patients and families. These researches provide evidence-based practices geared toward the specific needs of patients, and to increase awareness of palliative care programs and the special needs of nurses who care for dying.

Need for additional research in palliative care

Further research studies are needed to explore strategies to decrease work-related stress in nurses caring for dying patients. Another beneficial study could involve clearly identifying the role of the nurse in paediatric palliative care programs and establishing protocols for staff development. These studies may also discover other innovative ways to increase satisfaction of patients, family members, and nurses overall.

There is much need to increase a robust research agenda, targeting resource-poor areas, where disease burden and poverty are high and where health care is limited. Nurses are in a key position to do this, as they are globally advocating for increased awareness of palliative care as a public health issue and a human right, educating citizens about vaccinations and other preventive measures, and consulting in the development of competencies for this care. Targeted areas may include: Exploring the relationship of pain and other distressing symptoms on quality and quantity of life, independence, function and disability, and developing interventions directed at their treatment in patients with advanced and chronic illnesses; Studying methods of improving communication between adults living with serious illness, their families and their healthcare providers; Evaluating models and systems of care for patients living with advanced illness and their families. Future research questions include the following: What are the barriers to pain and other symptom management related to palliative care? Why do some resource-poor countries have excellent availability of opioids for medical purposes and other countries do not? What role do nurses play in advocacy in promoting palliative care? What are the needs of dying patients and their families in Egypt? What interventions need to be developed/made available to meet these needs?

Challenges for Implementing Palliative Care

Healthcare systems and policies: the big challenge to Egyptian palliative care professionals is the development of hospice systems along with well-organized home-based services, lack of national health policies in support of palliative care development, focus on acute care, poor understanding and awareness of the role of palliative care in community, lack of legislation and accreditation of this new specialty discipline, lack of facilities and resources for palliative care, lack of communication with concerned departments, palliative and end-of-life care not prioritized in healthcare strategies, lack of long-term care and community services, no statistical data about how and where patients die, how many receive palliative care, and the characteristics of the caring process, and insufficient supplies and equipment. Raising the awareness and knowledge of palliative care among health care professionals and providers; monitoring and surveillance of the implementation of the national palliative care policy; introducing more core palliative care curricula at all levels of all health professional training; and educating the public.

Healthcare professionals: inadequate training for both health care professionals and general public about the necessity and importance of palliative care as integral part of cancer care, palliative care as a discipline is being seen as less prestigious, lack of interdisciplinary concepts and teams, negative attitude towards caring for dying patients fear of opioid use (fear of side effects and/or fear of prosecution), resources focused on curative treatments and acute care, and perceived sense of failure.

Patients and families: fear of addiction to opioids, fear of abandoning family members unrealistic hopes of cure, families also refuse admission to hospice which is considered as a place of death, isolated and unfriendly, diversity in religious interpretation of death and dying.

Poor accessibility of essential palliative care drugs: general lack of opioids and unavailability of opioids in remote areas, very strict opioid prescription and dispensing policies, lack of other essential medications lists, and poor accessibility of essential palliative care drugs. Other challenges include changing the current opioid dispensing regulation to enable emergency opioid prescription by phone or fax, and the expansion of palliative care services to a larger number of patients and illnesses throughout the country.

Lack of relevant training to healthcare workers: lack of palliative care education programmes at all levels, Lack of updated education and clinical training to both physicians and nurses.

Conclusion and Recommendations

Palliative care is an urgent humanitarian need worldwide for people with cancer and other chronic fatal diseases. Palliative care is particularly needed in places where a high proportion of patients present in advanced stages and there is little chance of cure.

Palliative care services should be provided from the time of diagnosis of life-threatening illness, adapting to the increasing needs of cancer patients and their families as the disease progresses into the terminal phase. They should also provide support to families in their bereavement. It is necessary to change the legislative system in Egypt in order to recognize and to integrate this new discipline.

The ministry of health and population should recognize palliative care as a new subspecialty for nurses, and expansion of palliative care services to a larger number of patients and illnesses throughout the country, considering home-based palliative care service is urgently and badly needed

Education and training of health professionals in palliative care should be provided by medical and nursing schools throughout the country. Postgraduate education in medicine and nursing and ensuing certification should be made available.

A close collaboration between medical and nursing associations to achieve this end will be needed and is highly recommended.

National Committee for Pain Relief and Palliative Care should be developed, and the latter committee should develop a national plan that involves education, clinical practice including opioids availability, accessibility and disposal, research, public policy, and evaluating and monitoring care plans and activities.

It is as important and essential to involve policy makers in the development of pain relief and palliative care services and clinics which meet the needs of the population in Egypt.

Encourage community share in the program by money donations, hospice places, volunteers and training.

Organize a national master or diploma degree in palliative care with reasonable training hours.

Palliative care guidelines provide a framework for the care needed for patients with serious and life-threatening cancers.

The coordination of palliative care services remains to be one of the most crucial aspects and one of paramount importance. As terminally ill patients and their families move between the different settings and healthcare agencies, they need the support and guidance of a healthcare professional familiar with their situation who can coordinate their care.

Effective palliative care services should be integrated into the existing health system at all levels of care, especially community- and home-based care. They should involve public and private sector and be adapted to the specific cultural, social and economic setting.

Approaches to improving the application of this care include education, training, and research endeavours.

Pain and palliative care education and training should be incorporated in the training curricula of all medical schools, family residents training program and all postgraduate oncology and other chronic disease nursing training program, also palliative-care certified physicians are going to be central in coordinating this kind of care, clinical nurse specialists in palliative care, who provide palliative care at both institutional and community settings throughout the country are also needed.

Changing the current opioid dispensing regulation and ensuring the availability of essential drugs,

In order to respond to the cancer priority needs in a community and make the best use of scarce resources, palliative care services should be strategically linked to cancer prevention, early detection and treatment services for both adults and children.


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  13. Tawfik MO (1993) Egypt: status of cancer pain and palliative care. J Pain Symptom Manage 8: 409-411.

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    17. Ozgul N, Koc O, Gultekin M, Goksel F, Kerman S (2011) Opioids for cancer pain: availability, accessibility and regulatory barriers in Turkey and the Pallia-Turk Project. J PediatrHematolOncol33: S29–32.

  1. Flynn P, Betancour H, Tucker J, Garberoglio C, Riggs M (2007) Culture, emotions, and breast self- examinations among culturally diverse women. Presented at the Annual Conference for the American Psychological Association San Francisco, California.

  2. BeyeneY (1992) Medical disclosure and refugees. Telling bad news to Ethiopian patients.West J Med 157:328-332.

  3. Sachedina A (2005) End-of-life: the Islamic view. Lancet 366:774-779.

  4. Searight HR, Gafford J (2005) Cultural diversity at the end of life: issues and guidelines for family physicians. Am Fam Physician 71:515-522.

低氘氫氣,低氘飽合氫水的 應用案例






# 患者同時接受醫生治療。並且進行健康飲食。其得以康復原因應歸功於醫學治療與其正確的醫療對策。




#低氘氫氣或許可以溶解脂肪。然呼吸氫氣無法到達全身。飽和氫水中的氫氣數量並不大。推論- HBW-03可能加速代謝。降低體重。

#低氘水的溶解力較一般水體高30%。推論- HBW-03可能將腎臟無法代謝的毒性物質代謝出來。因此改善了腎臟功能。


  1. 本案例所使用之氫氣為7N( 99.9999%) –低氘氫氣。請勿自行使 用低於7N之氫氣或-電解製氫設備產生之- 高氘氫氣。避免中毒。
  2. 本案例所使用為型號HBW-03(低氘氫水)。請勿自行使用非本型號之-水素水 或- 氫水機 所製液體。避免中毒。





2017/11/30 鄭媽媽至實驗室呼吸低氘氫氣及飲用HBW-03。



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  1. 本案例所使用之氫氣為7N( 99.9999%) –低氘氫氣。請勿自行使 用低於7N之氫氣或-電解製氫設備產生之- 高氘氫氣。避免中毒。
  2. 本案例所使用為型號HBW-03(低氘氫水)。請勿自行使用非本型號之-水素水 或- 氫水機 所製液體。避免中毒。

DDW+H2, 低氘 氫水, A Tasty Health-Enhancer

DDW+H2, 低氘 氫水, A Tasty Health-Enhancer

In October 2013, the famous international academic journal Anti-Ageing published an article from the Japan Matsumoto Medical Center, which revealed an important part of anti-ageing mystery and caused a tremendous sensation in the anti-aging field. The article revealed that the amount of hydrogen exhaled by centenarians was more than three times that of average healthy people. Based on the confirmation of extensive biological effects of hydrogen molecules on the human body in recent years, the article drew the following conclusion: An important reason for the longevity of centenarians was that more hydrogen was produced in their bodies. 

TIMES ASIA, the Asian version of Time Magazine, once published a report on Hunza, the famous Pakistani village of longevity, where there were many centenarians but few occurrences of cancer, heart disease, abnormal blood pressure or other common modern diseases. It was said that cancer had been absent there for at least 900 years. In short, they were considered the world’s healthiest people. This phenomenon attracted the attention of scientists from all corners of the world. As a result, one survey found that the local drinking and crop-irrigation water came all from melted ice and snow from surrounding mountains. The deuterium level in the water was also found to be below 133 PPM, much lower than the 150 PPM average measured in the plain area and the 155 PPM in the equatorial area. Thus, the secret to longevity in Hunza was uncovered – Deuterium-Depleted Water, DDW.

To produce quality DDW incurs quite high cost if the traditional evaporation-of-water process were applied for deuterium depletion. Hence an alternative solution was found to reduce DDW production cost. In most heavy water production facilities water with low level of deuterium (light water) is considered as sub-product or waste. Using this waste water as prime material DDW can be produced for consumption, at lower price. But the whole industrial process used to produce heavy water left strong, unnatural flavor in its waste water which in turn is used for production of DDW.

Part of the reason Hunza people enjoy extremely good health is related to drinking natural water with low level of deuterium. Their crops are grown with the same water too. And they drink their water without any thinking. It´s just natural, part of daily life. So how can makers of DDW achieve both of the goals—lower level of deuterium in their product and at the same time let consumers drink it pleasantly?

One maker in Taiwan succeeded in transforming high purity water into deuterium-depleted water (DDW) through a month long process. The deuterium level is lowered to about 110 ppm.

In the same process hydrogen of high purity  (99.99999 %, or 7N) was dissolved in DDW up to level of saturation (about 2.14% H2 volume in water, or 1.6 ppm expressed by weight ratio).

THIS Deuterium Depleted, Hydrogen Saturated water (DDW+H2) set a new standard for all DDW makers regarding PURITY and FLAVOR. Its Pleasant Taste would make consumers actually ENJOY the drinking of DDW. The sensation of satisfaction and enjoyment caused by drinking something so simple as water (DDW+H2) for sure would also help those consumers with certain health issues. The only warning issued by the DDW+H2 maker in Taiwan to general consumers is that they do not encourage full replacement of daily consumption of water with their DDW+H2 since their products do not contain either minerals nor trace elements.

When You Drink DDW

When you drink DDW

It would lower Deuterium content in your blood

Basic parameters:

  1. An average person with a weight of 65 kgs has more or less 5,000 ml of blood.
  2. Typical drinking water has 150 ppm of Deuterium in the water.
  3. Most people in the world may have 150 ppm of Deuterium in their blood.
  4. Any water which has lower than 130 ppm Deuterium is considered as Deuterium Depleted.
  5. DDW product mentioned in this article contains 110 ppm of Deuterium and 2% of Hydrogen (volume, dissolved in water)
  6. DDW+H2 drinking volume for each day is established as 250 ml.
  7. For better results, at least a 90-days-DDW-drinking regimen should be considered.

Drinking DDW+H2:

Select a convenient hour. Every day at the same hour drink one 250 ml bottle of DDW.

250 ml DDW with 110 ppm Deuterium will get into blood which has 150 ppm Deuterium.

In the first day Deuterium in blood will be diluted to 148 ppm, or approximately 2 ppm lower.

In the second day Deuterium in the blood will be lowered 2 ppm further.

While drinking more DDW may drive Deuterium ppm lower in the blood, the actual amount of Deuterium ppm lowered by dilution would be less and less everyday until reaching a balance point which should be slightly higher than 110 ppm.

After drinking DDW+H2 water, the saturated Hydrogen eventually would be released inside body and be attracted to Hydroxylradical (OH), free radical. Hydrogen and OH will react and transform into water.

Deuterium content in water mentioned above is expressed as HDO and DDO.

DDW Research Resources

1) Revealing water’s secrets: deuterium depleted water


The ob value of the kinematic viscosity (1.46 mm2/s) has been found for 96.5 ppm D/H ratio. The significant deviation in surface tension values has been observed in deuterium depleted water samples at the both temperature regimes. The experimental data provides direct evidence that density, surface tension and viscosity anomalies of water are caused by the presence of variable concentration of deuterium which leads to the formation of water clusters of different size and quantity.tained results show the important role of the deuterium in the properties of bulk water. At 4°C the lowest

2) Deuterium depleted water effects on survival of lung cancer patients and expression of Kras, Bcl2, and Myc genes in mouse lung



Although advances in cancer therapies continue to develop, the shortness of the survival of lung cancer patients is still disappointing. Therefore, finding new adjuvant strategies is within the focus of cancer cure. Based on observations that deuterium depletion inhibits the growth of cancer cell lines and suppresses certain proto-oncogenes, we have conducted a clinical study in 129 patients with small cell and nonsmall cell lung cancers who consumed deuterium-depleted drinking water (DDW) as a nontoxic agent in addition to conventional chemotherapy and radiotherapy. Median survival time (MST) was 25.9 mo in males and 74.1 mo in female patients; the difference between genders was statistically significant (p < 0.05). Median survival of subjects with brain metastasis was 27.1 mo. Cumulative 5-yr survival probabilities were 19%, 52%, and 33% in males, females, and all patients with brain metastasis, respectively. Gene expression analysis in mouse lung indicated that DDW attenuates 7,12-dimethylbenz(a)anthracene (DMBA)-induced expression of Bcl2, Kras, and Myc in females. In conclusion, DDW counteracts the DMBA-induced overexpression of Bcl2, Kras and Myc genes in mouse lung, and it may extend survival of lung cancer patients as a nontoxic anticancer dietary supplement, especially for women with tumors overexpressing cancer-related genes, because MST of DDW-consuming group was 2-4 times longer than it is generally observed in lung cancer patients.

3) Research progress of the inhibitory effect of deuterium-depleted water on cancers



Deuterium is an important predisposing factor for cancer. Deuterium-depleted Water, also known as low deuterium water, ultra-light water or no deuterium water, can be obtained by removing deuterium from natural water. Studies have shown that water with a low deuterium concentration (<65% percent of volume) can inhibit cancer growth. Clinical trials demonstrated that drinking DDW (10-20 ppm) caused growth arrest of malignant cells in cancer patients and significantly prolonged the patient survival with also improved quality of life. A wide range of anti-cancer drugs in current use are associated with severe adverse effects, while deuterium-depleted water appears to have virtually no pharmacological side effects and is convenient to administer. The authors review the advances in the researches of anti-cancer effects and the underlying mechanisms of deuterium-depleted water.

4) Deuterium-depleted water selectively inhibits nasopharyngeal carcinoma cell proliferation in vitro



To evaluate the inhibitory effect of deuterium-depleted water (DDW) on the proliferation of nasopharyngeal carcinoma (NPC) cells in vitro and explore the possible mechanism.


The growth inhibition of NPC cells and preosteoblast MC3T3-E1 cells following DDW treatment was measured by MTT assay and plate colony formation assay. The changes in migration and invasion of NPC cells were evaluated using Transwell and boyden chamber assays. The protein expression of proliferating cell nuclear antigen (PCNA) was determined using Western blotting. Flow cytometry was employed to evaluate the changes in cell cycle distribution after DDW treatment.


DDW with deuterium concentrations of 100, 75 and 50 ppm significantly suppressed the cell proliferation (P<0.05) and lowered colony formation capacity and invasiveness of the NPC cells (P<0.01). Western blotting demonstrated a down-regulated expression of PCNA in the cells by DDW. DDW also caused obvious cell cycle arrest in the NPC cells with reduced cells in S phase and significantly increased cells in G(1) phase (P<0.05). Rather than causing growth inhibition, DDW promoted the growth of normal control MC3T3-E1 cells.


DDW possesses selective biological effects to inhibit the proliferation of NPC cells in vitro, suggesting the potential of DDW as a novel nontoxic adjuvant therapeutic agent in antitumor therapy.

5) Biological significance of naturally occurring deuterium: the antitumor effect of deuterium depletion



The concentration of deuterium is about 150 ppm (over 16 mmol/L) in surface water and more than 10 mmol/L in living organisms. Experiments with deuterium depleted water (30+/-5 ppm) revealed that due to D-depletion various tumorous cell lines (PC-3, human prostate, MDA, human breast, HT-29, human colon, M14, human melanoma) required longer time to multiply in vitro. DDW caused tumor regression in xenotransplanted mice (MDA and MCF-7, human breast, PC-3) and induced apoptosis in vitro and in vivo. Deuterium depleted water (25+/-5 ppm) induced complete or partial tumor regression in dogs and cats with spontaneous malignancies, it was registered as anticancer for veterinary use in 1999 (Vetera-DDW-25 A.U.V., 13/99 FVM). The hypodermic preparation of the registered veterinary drug was successfully tested in clinical investigations. Under the permission of the Hungarian Institute of Pharmacology (No. 5621/40/95) a randomized, double blind controlled, human Phase II clinical trial with prostate cancer was performed, in compliance with GCP principles, which exhibited a significant difference between the control and treated groups with respect to the examined parameters, median survival time and the extension of life-span. We suggest that cells are able to regulate the D/H ratio and the changes in the D/H ratio can trigger certain molecular mechanisms having a key role in cell cycle regulation. We suppose that not the shift in the intracellular pH, but the concomitant increase in the D/H ratio is the real trigger for the cells to enter into S phase. The decrease of D concentration can intervene in the signal transduction pathways thus leading to tumor regression. Deuterium depletion may open new perspectives in cancer treatment and prevention helping to increase the effectiveness of current oncotherapies.

DDW and H2 Lab

Better understanding of water, especially Deuterium Depleted Water (DDW) and Hydrogen is essential  for personal health improvement.



What is deuterium-depleted water (DDW)?

All natural water contains deuterium. The amount of deuterium varies from 90 ppm (parts per million) in melted Antarctic ice to 180 ppm in underground water below the Sahara desert. Typical drinking water has a deuterium concentration of about 150 ppm in most part of the world. Water with a deuterium concentration less than 130 ppm is considered deuterium-depleted. According to clinical work conducted in several countries, even this seemingly small reduction in deuterium content can have a significant and positive influence on a number of health issues. Deuterium, also called heavy hydrogen, is an isotope of hydrogen that contains one proton and one neutron.
Deuterium and DNA

Although mainstream researchers have overlooked the long term effects of low-level deuterium, research indicates that deuterium is coupled with DNA mutation and subsequent DNA damage. Deuterium affects the shape of molecules, including the shape of enzymes—many of which are involved in DNA synthesis and repair. The presence of deuterium in these enzymes slows DNA replication, it causes errors in transcription, and it hinders DNA repair.

Deuterium also has an effect on biological processes through the mechanism of hydrogen bonding. The bonds created by deuterium are stronger than normal hydrogen bonds. Tighter deuterium bonding stiffens proteins and requires more energy to break during metabolic reactions. Hydrogen bonds play a major role in DNA structure and are responsible for its helical shape. The class of enzymes and proteins that play a role in DNA replication and repair make extensive use of hydrogen bonds—another reason deuterium has negative effects on DNA.

Deuterium also interferes with normal proton movement in any proton channel—including the channels involved in ATP (energy) production. Its presence causes the mechanism to “stutter”  reducing efficiency. With normal concentrations of deuterium, the “stutter” happens about once every 15 seconds in every proton channel. Multiplied by the millions of proton channels in a living organism, this approaches monumental proportions. Given these affects (and others), deuterium is now thought to play an important role in the progression of disease and aging.

Deuterium and Aging

The most widely accepted theory on aging supposes that the aging process is correlated with a gradual accumulation of errors in DNA. According to Kirk Goodall, a senior member of the technical staff with NASA, the number of irreversible errors in the DNA sequence is directly influenced, by deuterium. The lower the deuterium concentration, the lower the frequency of the irreversible errors in DNA structures.

Biological effects of deuterium-depleted water (DDW)
Since water is a major source of hydrogen, and since most living organisms are 50 – 75% water, scientists have begun to investigate the effects of deuterium-depleted water—water with a reduced amount of deuterium. Discoveries in the last fifteen years have been groundbreaking. The biological effects of deuterium-depleted water (DDW) have been highlighted in dozens of studies conducted on plants, animals and humans.

Experiments on plants show a general increase in growth and productivity—up to 200%. Experiments with chickens lead to a 50% decrease in mortality and a near doubling in egg production. Experiments with mice revealed increased life expectancy and an increase in sexual activity.

Ten years of research and clinical trials on humans in Hungary by Dr. Gábor Somlyai and his colleges have identified positive effects of DDW in treating diabetes and many types of cancer. His book, Defeating Cancer: The Biological Effect of Deuterium Depletion, chronicles the work. Not only does the consumption of DDW affect the progression of many diseases and metabolic disorders (including hypertension, obesity, and diabetes), according to research conducted in Russia, it also positively affects energy production and immune function. A growing body of evidence shows DDW stimulates skin regeneration, reduces inflammation and slows aging. It also mitigates the damaging effects of radiation (nausea, pain, hair loss).


Cell´s lifespan? 

“The cell is immortal. It is merely the fluid in which it floats that degenerates. Renew this fluid at regular intervals, give the cells what they require for nutrition, and as far as we know, the pulsation of life can go on forever.” Dr. Alexis Carrell, Nobel prize winner.

Why drink deuterium-depleted water (DDW) ?
Research shows that consumption of DDW gradually reduces the deuterium concentration in the human body. Over a period of weeks and months, consumption of DDW allows the body to expel excessive deuterium from the body. This could reduce the ongoing, adverse effects of deuterium (ie. DNA errors during replication and repair). At the same time, a number of health parameters may improve. Dr. Somlyai’s work in Hungary revealed that healthy cells respond well to reduced amounts of deuterium in water. However, cells with chromosomal mutations (like cancer) are more sensitive to deuterium depletion. Cancer cells, particularly tumor cells, cannot adapt quickly, resulting in tumor regression without any side effects on healthy cells.